If you can find words in Scrabble that are 6-letters long then you can score a substantial number of points.
The average word on this list of 6-letter words ending in the letters IE is worth 10 points. But, you can score higher. The highest scoring word on this list is VIZZIE. It is worth 27 points.
If you can find a word worth 27 points in Words With Friends or Scrabble it can make the difference between winning and losing.
With that being said, it could be worth having a looking at all of the 6-letter words with IE and all of the words ending in IE given that we have already established that you do have the letters IE amongst your tiles.