The list of 6-letter words starting with DE that you can find on this page come from the WordsRated dictionary, the Scrabble dictionary (both US and UK), and the Words With Friends dictionary. If you wish to select a specific dictionary then you can do that using the form on the right-hand side of the page.
In total, there are 315 6-letter words on this list. On average, they are worth 9.8 if you are able to find the words on Scrabble or Words With Friends.
But the best word of the lot is worth 19 points. The word is: DEFUZE.
Beyond this list of 6-letter words starting with DE, we also have lists of related words including: 6-letter words ending in DE, 6-letter words with DE and words starting with DE.