With the help of the WordsRated word finder tool, we have managed to pull a list of 6-letter words from our range of dictionaries that begin with the letters TWE.
Because TWE is a very specific search term, we have only been able to identify 18 words.
However, that does make it very easy to find the word that is worth the most points out of all of these. In this case that word is: TWEEZE. It is worth 18 points in a game of Scrabble or Words With Friends.
You can also see the complete list of 6-letter words that start with various combinations of letters here.